Klinefelter's/xxy an orientation

[CC]

Introduction
This booklet was written and published in the light of a tremendous need for further information on Klinefelter's syndrome.

It is in no way an attempt of giving a complete description of all aspects of Klinefelter's syndrome.

The booklet was written in order to give a better information to Klinefelter-boys and their parents as well as to adult males with Klinefelter's syndrome, but it is also our hope that it will be read by genetic counsellors, physicians, teachers and others who come into contact with boys and adult males with Klinefelter's syndrome. More information on all levels will, however, first and foremost be valuable to Klinefelter-males and their relatives.

Publication by the Danish National Society of Turner Contact Groups should be seen as an expression of this society's wish to participate in the spreading of knowledge of Klinefelter's syndrome and create the possibility of establishing Klinefelter contact groups. Furthermore, to make an information, counselling and research center for people with Turner's syndrome and other sex chromosome abnormalities such as Klinefelter's syndrome, triple-X and XYY syndrome.

Johannes Nielsen

http://www.aaa.dk/TURNER/ENGELSK/KLINE.HTM


Another great link would have to be
http://emedicine.com/PED/topic1252.htm

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[Az1]

XX oh yea and y.
You can read my other 100's of post here on BLO.
I have already read and seen the information published by XXy medical evauluators. So what. To me I read Blah Blah Blah.
I was told By a Naval Officer I am Infertile and was born with XXy. She was quite blunt and I Felt like I had a place in her Navy. I also did not feel normal or of a male at the time I was told.
I was born, yee haw. Then growing up I was lied too yee haw gidddy up.
Now that I am in an age to decide what or who I am I get mixed emotions from both male and female gender.
I am Intersexed, I was born with AIS and identify as a female.
I have alwaays identified as a female but was told in a ruthless manner that I was a man and that I am not supposed to get into female intuitions and female idealisms. I try to stay in the middle where males identify me as who they think I am and females who they think I am.The rest is my own dysfunction. I have tried to explain myself and have always been sterotyped.

Az1

[CC]

Hi Az1

do you have a name other than Az1
Now that I am in an age to decide what or who I am I get mixed emotions from both male and female gender.

I can both understand and relate

I am Intersexed, I was born with AIS and identify as a female.

I'm intrigued,did you get a diagnoses of AIS in conjunction with XXy,I never knew that was possible and if so,I would like to learn more,if you are willing to share.

I try to stay in the middle where males identify me as who they think I am and females who they think I am.

I understand and try not to apply any labels to myself as to what gender I am,even though I present as male (wear male/unisex clothing) and work in a male dominated industry,my homone of choice(as an XXy) is certainly not testosterone.In the past,upon diagnoses,I tried to "slot in" to gender role and failed miserably.

Kindest regards

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[Dana Gold]

AIS in conjunction with XXy,I never knew that was possible
It is possible, but probably quite rare.....excerpt from abstract (link below); the parentheses are mine

An 11-year-old patient with incomplete (partial) testicular feminization (outdated terminology for AIS)and a 47,XXY karyotype is described. The patient had female external genitalia, clitoromegaly, and some features of Klinefelter's syndrome, including speech delay and delayed intellectual development. DNA analysis using X chromosomal DNA sequences suggest that the supernumerary X chromosome in the patient resulted from maternal nondisjunction during meiosis II. The M II error thereby provides the basis for homozygosity of a mutation in the androgen receptor locus.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=2303249&dopt=Abstract

[Az1]

I say what is true and what is in my heart. I have to deal with all that applies and always struggling to do better.
I do not want to be labeled either but we live in a world where justifcation of a label, society can identify with to make it their own understanding of what other individuals are so society will have an understanding to their own degree of normalcy.
I go by Az1, I perfer this nickname because I am sure I will never be Az1

Az1

ES. Thank you Dana.

[CC]

It is possible, but probably quite rare.....excerpt from abstract (link below)
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=2303249&dopt=Abstract

Hi Dana

My reason for asking was,that I had never heard of such cases before,indeed I have asked around on various xxy related lists/forums in regards to this and as of yet have recieved zero replies.Like you said "It is possible, but probably quite rare"

I noticed the link you supplied is from a report which is almost 15yrs old,is it possible with the advancement in medicine that,the condition is known by another name,instead of AIS in conjunction with XXY.The following information was taken from the Androgen Insensitivity Syndrome
Support Group (AISSG).................

Genetics - AIS
There are a number of abnormalities of the sex chromosomes that can occur. One example is Klinefelter's Syndrome, in which a man carries an extra X chromosome. Another is Turner Syndrome in which a woman is missing an X chromosome. AIS is not a disorder of the sex chromosomes, because the sex chromosomes in an AIS baby are those of a normal male, XY. The genetic fault lies in the Androgen Receptor (AR) gene on the X chromosome received from the mother. This affects the responsiveness, or sensitivity, of the foetus's body tissues to androgens
http://www.medhelp.org/www/ais/21_OVERVIEW.HTM#FormsAIS

Canice