hypospadias etc.

[Dana Gold]

Whether or not hypospadias ........... is an intersex condition,

I think that an intersex condition can be accompanied by hypospadias and epispadias, especially when the hypospadias are proximal to the scrotum base and there is concurrent involvement of other dysgenic factors of the reproductive organ systems. However any degree (especially milder forms, distal-coronal/glans) of hypospadias are not considered to be an intersex condition....that is the phenotype and genotype are "normal" male; wherein penile and testicular size and function are also normal.

Below is a ( warning :graphic ) medical link depicting photos of various congenital conditions involving the external reproductive organs.

http://www.atlasperovic.com/contents/index.htm

Additional link (Pathology) of testicular (and penile "disorders" ..including agenesis of both):

http://pathologyoutlines.com/testis.html

http://www.pathologyoutlines.com/penscrotum.html

For any "geneticists" here:

http://pathologyoutlines.com/chromosomes.html



Dana :pizza:

[Dana Gold]

Excerpt from link below it....note: AR stands for Androgen Receptor

Differential Diagnosis

For current information on availability of genetic testing for disorders included in this section, see GeneTests Laboratory Directory. —ED.

Hypospadias that results from an AR gene mutation (and thus is part of the spectrum of PAIS) cannot be distinguished from hypospadias resulting from other (largely undefined) causes by the examination of the genitalia alone. Several investigators have determined how often hypospadias of varying severity can be attributed to AR gene mutations. In studies using mutation scanning, Sutherland et al (1996) found one AR gene mutation among 40 subjects with penile hypospadias, while Hiort et al (1994) found no AR mutations in 12 individuals with coronal (glandular) or penile hypospadias, but did find one individual with an AR mutation among nine individuals with severe (penoscrotal, perineal) hypospadias. Batch et al (1992 , 1993) found an AR mutation in two brothers with isolated severe (perineal) hypospadias. Allera et al (1995) sequenced the AR gene in nine individuals with isolated severe hypospadias and found an AR mutation in one. McPhaul et al (1997) found that two of the remaining eight individuals originally studied by Allera et al (1995) had androgen receptors that were transactivation deficient when their genital skin fibroblasts were infected with a recombinant adenovirus carrying an androgen-responsive reporter gene.


http://www.geneclinics.org/profiles/androgen/details.html

[kayleighsmom]

Dana,

I consider myself so lucky to have met you! Do you know how long I have searched for information exactly like this and had a hard time finding it. You are so smart girl! Thank you for sharing this!!

Hope to talk with you again soon!

Lindakaye

[Betsy]

Hey Dana,

Not sure if you noticed this little feature in the new site...

http://www.bodieslikeours.org/component/option,com_newsfeeds/task,view/feedid,20/Itemid,199/

Don't bookmark it though as I'm in the process of converting the urls to some that are more friendly so it will change.

Betsy

[Dana Gold]

Thank you :smile: , Betsy!

I forgot to remember there's much more to BLO than just our community forum :doh: , especially now with the updated, new format. :thumbs_up

Don't bookmark it though Okey-Dokey, Betsy.

Thank you for sharing this!! You're very welcome, glad to be of service.....that'll be $150 for "consultation" fees :eek:

JUST KIDDING!! :wink_smil

Dana